Anticholinergic
An anticholinergic agent is a member of a class of pharmaceutical compounds which serve to reduce the effects mediated by acetylcholine in the central nervous system and peripheral nervous system. Anticholinergics are typically reversible competitive inhibitors of one of the two types of acetylcholine receptors, and are classified according to the receptors that are affected: antimuscarinic agents operate on the muscarinic acetylcholine receptors, and antinicotinic agents operate on the nicotinic acetylcholine receptors. The majority of anticholinergics are antimuscarinics.
Effects
When a significant amount of anticholinergic is taken into the body, a toxidrome known as acute anticholinergic syndrome may result. This may happen accidentally or intentionally as a form of recreational drug use. This class of drug is usually considered the least "fun" by experienced drug users. Because most users do not enjoy the experience, they don't use it anymore, or very rarely. Risk of addiction is low in the anticholinergic class. Possible effects of anticholinergics in the peripheral nervous system include: Ataxia; loss of coordinationDecreased mucus production in the nose and throat; consequent dry, sore throatPrevention of salivationStops perspiration; consequent increased thermal dissipation through the skin leading to hot, red skinIncreased body temperaturePupil dilation (mydriasis); consequent sensitivity to bright light (photophobia)Loss of accommodation (loss of focusing ability, blurred vision — cycloplegia)Double vision (diplopia)Increased heart rate (tachycardia)Urinary retentionDiminished bowel movement, sometimes ileusIncreased intraocular pressure, dangerous for people with narrow-angle glaucoma Possible effects in the central nervous system resemble those associated with delirium, and may include: ConfusionDisorientationAgitationRespiratory depressionShort-term memory lossInability to concentrateWandering thoughts; inability to sustain a train of thoughtIncoherent speechWakeful myoclonic jerkingUnusual sensitivity to sudden soundsIllogical thinkingVisual disturbances*Periodic flashes of light*Periodic changes in visual field*Noisy vision*Restricted or "tunnel vision"Visual, auditory, or other sensory hallucinations*Warping or waving of surfaces and edges*Textured surfaces*"Dancing" lines; "spiders", insects*Lifelike objects indistinguishable from realityRarely: seizures, coma Acute anticholinergic syndrome is completely reversible and subsides once all of the toxin has been excreted. Ordinarily, no specific treatment is indicated. However, in extreme cases, especially those that involves severe distortions of mental state, a reversible cholinergic agent such as physostigmine may be used.
Plant sources
The most common plants containing anticholinergic alkaloids are:Atropa belladonna (Deadly Nightshade)Mandragora officinarum (Mandrake)Hyoscamus niger (Henbane)Datura species (Datura)
PharmaceuticalsMuscarinic receptor antagonists*Belladonna alkaloids**Scopolamine (L-Hyoscine)**Atropine (D/L-Hyosycamine)*Synthetic and Semisynthetic**Dicyclomine**Flavoxate**Ipratropium**Oxybutynin**Pirenzepine**Tolterodine**TropicamideNicotinic receptor antagonists*Ganglionic blocking agents**Trimethaphan*Nondepolarizing neuromuscular blocking agents**Atracurium**Doxacurium**Mivacurium**Pancuronium**Tubocurarine**Vecuronium*Depolarizing neuromuscular blocking agents**Suxamethonium chloride Many other drugs have anticholinergic properties, including cyclic antidepressants and the common allergy medications diphenhydramine (Benadryl) and its 8-chlorotheophylline salt dimenhydrinate (Dramamine), which are used medically for antihistaminergic and antiemetic purposes, and sometimes recreationally for their psychoactive effects. The common side effects of some SSRI antidepressants, such as Prozac (fluoxetine), often sweaty palms, are due to anticholinergic properties.
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