DNA ligase

In molecular biology, DNA ligase is an enzyme that repairs broken DNA strands. DNA ligase (EC 6.5.1.1) is a particular type of enzyme that can form covalent phosphodiester bonds and ligate or connect (broken) DNA strands.

An example of how a ligase works (with sticky ends):

5'-AGTCTGATCTGACT GATGCGTATGCTAGTGCT-3' 3'-TCAGACTAGACTGACTACG CATACGATCACGA-5' becomes 5'-AGTCTGATCTGACTGATGCGTATGCTAGTGCT-3' 3'-TCAGACTAGACTGACTACGCATACGATCACGA-5'

External links

DNA Ligase: PDB molecule of the month

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