Haemolytic disease of newborn
Haemolytic disease of newborn, as the name implies, affects the fetus or neonate, and results from the transplacental passage of maternal antibodies against fetal red cell antigens inherited from the father. Over 90% of all cases of clinically significant haemolytic disease of newborn affect rhesus D (RhD)-positive infants born to RhD-negative mothers. The mothers usually make the antibodies after a fetomaternal haemorrhage at delivery of the first RhD-positive infant. This does not harm the infant, but successive RhD-positive infants are then progressively more affected by the maternal antibodies. External Link NHS HTA programme HDN info
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